About statistical proof, there is statistical proof on which 24 hour alerts are issued so I was interested to note that the French PET scan study of cortical spreading depression also reported a 24 hour time frame from it's initiation to a full blown Migraine attack, so I wonder if the two 24 hour time frames are just coincidence or are they one and the same result due to the electrical charge of the air changing with the weather? My feeling is that individual life circumstances are powerful determinants of how we react to a given weather pattern and I see no problem with linking this to the findings of the Australian Biochemist. As you know Bipolar depression has been found to have a seasonal component and speaking for my own family I have noticed the down part of the condition appears to share something in common with increased Mediclim warnings for Migraine around this time of year. I wonder if a survey of migraine episodes and seasonal Migraine alerts may help provide statistical evidence and also raise the credibility status of Mediclim. Regards